The Impact of Infection Versus Colonization on Clostridioides difficile Environmental Contamination in Hospitalized Patients With Diarrhea

Hot off the press from the DiRTE Lab, the newest addition to the DCASIP, Lab Director Bobby Warren and his team take us through their work studying environmental contamination from patients with CDI. 

Impact of Education and Data Feedback on Antibiotic Prescribing for Urinary Tract Infections in the Emergency Department: An Interrupted Time Series Analysis

The ASET team led a study on antibiotic prescribing for UTIs in emergency departments published in the journal Clinical Infectious Diseases. 

Urinary tract infections (UTIs) are often misdiagnosed or treated with exceedingly broad-spectrum antibiotics, leading to negative downstream effects. We aimed to implement antimicrobial stewardship (AS) strategies targeting UTI prescribing in the emergency department (ED).

SARS-CoV-2 Environmental contamination in hospital rooms is uncommon using viral culture techniques

Our lab team, led by Director Bobby Warren, assessed environmental contamination of inpatient rooms housing COVID-19 patients in a dedicated COVID-19 unit. Contamination with SARS-CoV-2 was found on 5.5% (19/347) of surfaces via RT-PCR and 0.3% (1/347) of surfaces via cell culture. Environmental contamination is uncommon in hospitals rooms; RNA presence is not a specific indicator of infectious virus. The team's findings can be found in Clinical Infectious Diseases.

Impact of Education and Data Feedback on Guideline-Concordant Prescribing for Urinary Tract Infections in the Outpatient Setting

Urinary tract infections (UTIs) are the most common outpatient indication for antibiotics and an important target for antimicrobial stewardship (AS) activities. With The Joint Commission standards now requiring outpatient AS, data supporting effective strategies are needed.

Clinicians increased guideline-concordant prescribing, reduced UTI diagnoses, and limited use of high-collateral damage agents following this outpatient AS intervention. Routine data feedback was effective to maintain the response to the initial education.

This is an open access article. 


Endogenous Candida Endophthalmitis: Who is Really at Risk?

The Infectious Disease Society of America recommends that all patients with candidemia undergo a dilated retinal exam to exclude endogenous Candida endophthalmitis. The objective of this project was to determine if there are significant risk factors in candidemic patients for developing endogenous Candida endophthalmitis. 

Compiling Observational Research During a Pandemic: A Necessary Bridge

Dr. Rebekah Moehring and Dr. Thomas Holland talked with Clinical Infectious Diseases Journal about compiling observational research ruring a pandemic. 

Impact of preoperative chlorhexidine gluconate (CHG) application methods on preoperative CHG skin concentration

Led by DCASIP Clinical Ressearch Coordinator (CRC) Bobby Warren, along with CRC Alicia Nelson and Medical Director Dr. Dev Anderson, a team from multiple medical centers in the CDC Prevention Epicenters Program worked to find the impact of preoperative chlorhexidine gluconate (CHG) application methods on preoperative CHG skin concentration. 

Measuring the impact of continuous disinfection strategies on environmental burden in outpatient settings: a prospective randomized controlled trial

The primary objective of this study by the CDC Epicenters Program, led by DCASIP Clinical Research Coordinator Bobby Warren, was to determine the effectiveness of two enhanced disinfection strategies compared to standard disinfection: “near-UV” light (Arm 1) and a persistent organosilane quaternary ammonium disinfectant (Arm 2) using a triple-blind study design. The secondary objective was to characterize environmental contamination of outpatient clinics.

Tap Water Avoidance Decreases Rates of Hospital-Onset Pulmonary Nontuberculous Mycobacteria

Combined efforts from DCASIP faculty, led by Dr. Art Baker, with faculty from the Infectious Diseases Divisions at Duke University Medical Center and the Durham VA Hospital resulted in the latest publication in the journal Clinical Infectious Diseases: Tap Water Avoidance Decreases Rates of Hospital-Onset Pulmonary Nontuberculous Mycobacteria (link to the abstract).

Healthcare associated diarrhea, not Clostridioides difficile

Dr. Nick Turner et al. worked together on an article published in Current Opinion in Infectious Diseases regarding healthcare-associated diarhhea (HCAD). The link to the listing is available here